Patrick retired from shooting scenes in the adult industry in 2008 but continues to operate her website, production company, and pursue other business ventures. She licenses her movie catalog worldwide.
Patrick has appeared in Playboy and Penthouse, where she was the "Pet of the Month" for February 2000 and was selected as "Pet of the Year" runner-up. In 2003, Patrick became the masthead publisher of Genesis.
In 2006, Patrick and her then-husband, Evan Seinfeld, launched a talent agency representing models and actors. According to a quote on the agency's website, Patrick's goal "is to help girls (and guys) in the business to be treated with respect, and realize their true potential...." Additionally, she owns a production company called "Teravision," which along with Vivid Video released its first feature, Desperate, starring Patrick and Seinfeld. In April 2006, it was announced that she would host the Exxxotica Miami convention.
In November 2006, Patrick starred in a Vivid/Teravision production titled "Tera Patrick's Fashion Underground" where she performed with Jean Val Jean and Tommy Gunn. In the same film her husband, under the name Spyder Jonez, performed with Lanny Barby. In an interview, Tera Patrick says she's OK with him doing scenes with other girls. The two made five movies for Vivid and ten for Teravision (with Seinfeld appearing under the name "Spyder Jonez"; he has also directed some features).
In an interview with the Adult Film Database in February 2007, Patrick stated she would only continue to work in front of the camera for two more years, but planned on releasing her starring adult titles over the next decade.
Patrick promoting her character in the video game Backyard Wrestling 2 in 2004
In April 2007, Patrick and her production company, Teravision INC, filed a lawsuit against Jenna Jameson and Playboy Enterprises (the new owners of Club Jenna) for failing to properly account for and pay royalties on money earned by Patrick's Web site clubtera.com.
In 2008, Patrick began hosting the Playboy TV erotic instructional show, School of Sex. She was also the host for 25th AVN Awards ceremony.
In January 2013, Patrick hosted the annual XBIZ Awards.