Dave shocks the audience with the news that Oprah Winfrey will be a guest on the show a week from Thursday; Biff undergoes Lasek eye surgery; George Clooney promotes "Syriana."
Where to Watch George Clooney, Ashlee Simpson
Cast of George Clooney, Ashlee Simpson
David LettermanSelf - Host
Paul ShafferSelf -Musical Director
Alan KalterSelf - Announcer (voice)
Jerry FoleyDirector
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