Of French-Irish origin, Alison Wheeler was born on July 22, 1986, in Enghien-les-Bains in Val-d'Oise. After graduating with a Baccalauréat diploma in humanities at Notre-Dame-de-Bury High School, (Margency), she took comedy classes at Cours Florent and Studio Pygmalion. She also studied at the university Paris-Sorbonne IV.
After having participated in several television series and co-hosted the show Kawai on Filles TV alongside Louise Bourgoin, Wheeler won a role in the Saphia Azzeddine's adaption of Azzeddizine's novel Mon père est femme de ménage. Her performance as the big sister who dreams of becoming a musical star earned her a nomination for the 2012 Césars as "most promising actress". She continued on to earn a small role in the biopic My Way, by Florent Emilio Siri, also released in 2012.
During the same year, Wheeler established her internet presence: first on the site MadmoiZelle.com and later through the internet cooperative Studio Bagel, which she joined in season 2, and which provided her with a wider audience. When Studio Bagel was acquired by the television channel Canal+, Wheeler became one of television's most prominent faces. She took part in the show Le Dézapping du Before, broadcast during le Before du Grand Journal, on the programme Carte de Presque and occasionally on the Grand Journal's JT de l'invité on Canal+. However, Wheeler's most recognizable work began on September 9th, 2014, as a presenter for the Grand Journal weather on Canal + with Monsieur Poulpe. She left Le Grand Journal in spring of 2015 to focus on cinema.