Saturday Night Live aired its sixteenth season during the 1990-1991 television season on NBC. 20 episodes were produced. The sixteenth season began on September 29, 1990, and ended on May 18, 1991.

The 16th season of SNL was a transitional one: Several longtime cast members left, and a large number of additions were made to the roster. To ensure that he was not short on talent, Michaels chose to retain most of the late 1980s cast while in the process of hiring the people that would make up the early 1990s cast. At one point during the season, sixteen people were listed as cast members or featured players.
20 Episodes
  • Kyle MacLachlan/Sinead O'Connor
    Kyle MacLachlan/Sinead O'ConnorEpisode 1
  • Susan Lucci/Hothouse Flowers
    Susan Lucci/Hothouse FlowersEpisode 2
  • George Steinbrenner/The Time
    George Steinbrenner/The TimeEpisode 3
  • Patrick Swayze/Mariah Carey
    Patrick Swayze/Mariah CareyEpisode 4
  • Jimmy Smits/World Party
    Jimmy Smits/World PartyEpisode 5
  • Dennis Hopper/Paul Simon
    Dennis Hopper/Paul SimonEpisode 6
  • John Goodman/Faith No More
    John Goodman/Faith No MoreEpisode 7
  • Tom Hanks/Edie Brickell and New Bohemians
    Tom Hanks/Edie Brickell and New BohemiansEpisode 8
  • Dennis Quaid/Neville Brothers
    Dennis Quaid/Neville BrothersEpisode 9
  • Joe Mantegna/Vanilla Ice
    Joe Mantegna/Vanilla IceEpisode 10
  • Sting
    StingEpisode 11
  • Kevin Bacon/INXS
    Kevin Bacon/INXSEpisode 12
  • Roseanne Barr/Dee-Lite
    Roseanne Barr/Dee-LiteEpisode 13
  • Alec Baldwin/Whitney Houston
    Alec Baldwin/Whitney HoustonEpisode 14
  • Michael J. Fox/The Black Crowes
    Michael J. Fox/The Black CrowesEpisode 15
  • Jeremy Irons/Fishbone
    Jeremy Irons/FishboneEpisode 16
  • Catherine O'Hara/R.E.M.
    Catherine O'Hara/R.E.M.Episode 17
  • Steven Seagal/Michael Bolton
    Steven Seagal/Michael BoltonEpisode 18
  • Delta Burke/Chris Isaak
    Delta Burke/Chris IsaakEpisode 19
  • George Wendt/Elvis Costello
    George Wendt/Elvis CostelloEpisode 20
Cast of Season 16
  • Dana CarveySelf - Various Characters
  • Dennis MillerSelf - Various Characters
  • Jon LovitzSelf - Various Characters
  • Jan HooksSelf - Various Characters
  • Victoria JacksonSelf - Various Characters
  • Phil HartmanSelf - Various Characters
  • Kevin NealonSelf - Various Characters
  • Mike MyersSelf - Various Characters
  • Chris FarleySelf - Various Characters
  • Chris RockSelf - Various Characters

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