Phil LaMarrOsmosis Jones (voice) Alanna UbachMayor Paul Spryman / Hector's Mom (voice) Justin CowdenHector Cruz (voice) Tasia ValenzaMaria Amino (voice) Jim CummingsPolice Chief Gluteus (voice) Rob PaulsenTravis Lum (voice) Vivica A. FoxEllen Patella (voice) Pat FraleyBrain Advisor #1 (voice) Frank WelkerDander (voice) Jeffrey TamborThe Mole (voice) Charlie AdlerGeneral Malaise (voice) Kimberly BrooksChristine Kolchuck (voice) Kevin Michael RichardsonRescue Cell (voice) Cree SummerMayor Santorini (voice) Tim CurryNick O'Teen (voice) Brad GarrettStrepfinger (voice) Dawnn LewisCilia Tyson (voice) Joe LalaHector's Dad (voice) Jim BelushiCaptain Quinine (voice) Kath SoucieNaurine / Celly Katz (voice) Andrea MartinAunti Histamine (voice) Candi MiloMumsy Glop (voice) Miriam FlynnDrixeen (voice) Justine BatemanRota (voice) Billy WestMuscle Cell (voice) Danny BonaduceSmirch (voice) April WinchellCafeteria Lady (voice) Wendie MalickNumber 2 / Sticky Flagella (voice) Jess HarnellShwee (voice) Julian SandsPenicillin G (voice) Henry WinklerSal Monella (voice) Brian PosehnSylvian Fisher (voice) Kathy NajimyLoretta Epstein (voice) Danny CookseyShane (voice) Hope LevyBrittany Estrogen (voice) Jeffrey GarciaRicardo Amino (voice) Dee Bradley BakerFather Glop (voice) 
