Filmography
| 2024 | ReEntry · as Elenore |
| 2023 | Big Boys · as Nicole |
| 2022 | Devil in Ohio · as Suzanne Mathis |
| 2022 | Continue · as Janet Tex |
| 2018 | The Rookie · as Sarah Nolan |
| 2016 | Animal Kingdom (2016) · as Angela |
| 2015 | Unity · as Narrator (voice) |
| 2014 | BoJack Horseman · as Bones (voice) |
| 2014 | Beyond Beyond · as The CaptainNo Plex |
| 2013 | Sleepy Hollow · as Dr. Temperance Brennan |
| 2013 | Drunk History · as Babe Didrikson |
| 2011 | The Perfect Family · as Shannon ClearyNo Plex |
| 2009 | The Cleveland Show · as Emily Deschanel (voice) |
| 2009 | My Sister's Keeper · as Dr. FarquadNo Plex |
| 2006 | Glory Road · as Mary Haskins |
| 2005 | Mute · as Claire |
| 2005 | Bones · as Temperance 'bones' Brennan |
| 2005 | American Dad! · as Emily Deschanel (voice) |
| 2005 | Boogeyman · as Kate HoughtonNo Plex |
| 2004 | Spider-Man 2 · as Receptionist |
| 2004 | The Alamo · as Rosanna Travis |
| 2003 | Cold Mountain · as Mrs. Morgan |
| 2003 | Easy · as Laura HarrisNo Plex |
| 2002 | Rose Red · as Pam Asbury |
| 2001 | Crossing Jordan · as Michelle |
| 1999 | Law & Order: Special Victims Unit · as Cassie Germaine |
| 1999 | Providence · as Annie Frank |
| 1994 | It Could Happen to You · as Paint-Throwing Fur Activist |
| 1992 | |
| 1989 | The Simpsons · as Emily Deschanel (voice) |
| 2022 | A Decent Home · as Executive Producer |
| 2012 | |
| 2005 | Bones · as Co-Producer |
| 2005 |