Andrew RannellsMatthew MacDell (voice) Nick KrollNick Birch / Maury the Hormone Monster / Coach Steve (voice) / Schrijver John MulaneyAndrew Glouberman (voice) Jessi KleinJessi Glaser (voice) Jason MantzoukasJay Bilzerian (voice) Maya RudolphDiane Birch / Connie the Hormone Monstress (voice) Fred ArmisenElliot Birch (voice) Jordan PeeleGhost of Duke Ellington (voice) Jenny SlateMissy Foreman-Greenwald (voice) Joe WengertCaleb (voice) / Story Ayo EdebiriMissy Foreman-Greenwald (voice) June Diane RaphaelDevin (voice) Richard KindMarty Glouberman (voice) Jessica ChaffinShannon Glaser (voice) Paula PellBarbara Glouberman (voice) Jon DalyJudd Birch (voice) Jak KnightDeVon (voice) / Schrijver Chelsea PerettiMonica Foreman-Greenwald (voice) Seth MorrisGreg Glaser (voice) Gil Ozeri(voice) / Schrijver Nathan FillionNathan Fillion (voice) Kat DenningsLeah Birch (voice) Gina RodriguezGina Alvarez (voice) David ThewlisShame Wizard (voice) Thandiwe NewtonMona (voice) Brandon Kyle GoodmanWalter the Lovebug (voice) / Schrijver Maria BamfordTito the Anxiety Mosquito (voice) Heather LawlessJenna Bilzerian (voice) Mark DuplassVal Bilzerian (voice) Paul ScheerKurt Bilzerian (voice) Zachary QuintoAiden (voice) Stephanie BeatrizLulu (voice) Emily AltmanVicky (voice) / Schrijver Chloe FinemanLeah Birch (voice) Rob HuebelMr. Lizer (voice) Natasha LyonneMs. Dunn (voice) Gary ColeAndrew's Father (voice) Jean SmartDepression Kitty (voice) Jack McBrayerPubic Hair #1 (voice) John GemberlingTyler the Hormone Monster (voice) Craig RobinsonPubic Hair #2 (voice) Michaela WatkinsCantor Dina Reznick (voice) Kristen BellPam the Pillow (voice) Ashley LondonThe Virgin Mary / Waitress (voice) Rosa SalazarMs. Benitez (voice) Quinta BrunsonQuinta (voice) Ayden MayeriGabrielle (voice) Andy DalyGhost of Harry Houdini (voice) Bobby CannavaleGavin the Hormone Monster (voice) Seth RogenSeth Goldberg (voice) Julie WhiteKimberly (voice) Sterling K. BrownMichael Angelo (voice) Kristen WiigJessi's Vagina (voice) Megan Thee StallionMegan the(e?) Hormone Monstress (voice) Patrick PageDread (voice) Ileen GoldsmithJessi Glaser - singing double / Judd's Girlfriend (voice) Brendan McCrearyFreddie Mercury (singing voice) Carlos AlazraquiGustavo (voice) Julie KlausnerCherry Marashina (voice) Josie TotahNatalie (voice) Joel Kim BoosterCharles Lu (voice) Judd HirschLewis Glouberman (voice) Billy PorterOcean (voice) J ValerioneB-High Qee-Choi Member (voice) Keke PalmerRochelle the Hate Worm (voice) Pamela AdlonSonya the Lovebug (voice) Jon GabrusMovie Theater Customer (voice) Anna GravesMrs. Albert (voice) Nasim PedradFatima (voice) Mae WhitmanTallulah Levine (voice) Chrissy GuerreroChoir Girl (voice) Philip QuinazTanya Alvarez (voice) Harvey FiersteinOlder Guy Town Resident (voice) Jerry MinorMan #3 / Singing Fish (voice) Piotr MichaelSiamese Twin #2 (voice) Marisa Lark WallinReese's Wertherspoon / Woman (voice) Martin ShortGordie (voice) David CrossSkip Glouberman (voice) Carol KaneMenopause Banshee / Old Woman (voice) RettaDuke's Mother (voice) Wanda SykesGhost of Harriet Tubman (voice) Jaboukie Young-White(voice) / Schrijver Rob RiggleSgt. Adderall (voice) Bobby BerkBobby Berk (voice) Karamo BrownKaramo Brown (voice) Tan FranceTan France (voice) Antoni PorowskiAntoni Porowski (voice) Jonathan Van NessJonathan Van Ness (voice) Maya ErskineMisha (voice) Alia ShawkatRoland (voice) Paul GiamattiAndrew’s Shit (voice) Adam ScottMr. Dylan Keating (voice) Hugh Jackmanhimself (voice) Kumail Nanjianihimself (voice) Jemaine ClementSimon Sex (voice) Kristen SchaalBernie Sanders (voice) Somali RoseMissy’s Overalls Lupita Nyong'oAsha (voice) Miranda TapsellKara (voice) Lin-Manuel MirandaPuerto Rican Pubic Hair (voice) Randall ParkPete Doheny (voice) Maitreyi RamakrishnanMarissa (voice) Ava LalezarzadehNazanin (voice) Don CheadleDon Cheadle (voice) Padma LakshmiPriya (voice) Zach GalifianakisGratitoad (voice) Jeff GoldblumThe Apple Brooch Eliseo RománEliseo Román (voice) Mike L. MayfieldRegisseur / Schrijver Gil Ozeri(voice) / Schrijver Emily AltmanVicky (voice) / Schrijver Jennifer FlackettSchrijver Nick KrollNick Birch / Maury the Hormone Monster / Coach Steve (voice) / Schrijver Jaboukie Young-White(voice) / Schrijver Jak KnightDeVon (voice) / Schrijver Joellen RedlingshaferSchrijver Brandon Kyle GoodmanWalter the Lovebug (voice) / Schrijver Jordan FirstmanConsulting Producer Charles BradleyTheme Song Performance Joe WengertCaleb (voice) / Story 
