Reese WitherspoonSusan Murphy / Ginormica (voice) Hugh LaurieDr. Cockroach Ph.D. (voice) Will ArnettThe Missing Link (voice) Kiefer SutherlandGeneral W.R. Monger (voice) Rainn WilsonWicked Jack (voice) Jeffrey TamborCarl Murphy (voice) Julie WhiteWendy Murphy (voice) Rich DietlB.O.B. Kid / Husband / Pumpkins (voice) Walt DohrnLink Kid (voice) Susan FitzerLittle Girl (voice) Ava KellyCat Girl (voice) Andrea Montana KnollMom (voice) Latifa OuaouBoy / Old Lady (voice) Peter RamseyDad / Farmer Jeb (voice) / 导演 Conrad VernonMan on Cell / Woman (voice) / 编剧 Peter RamseyDad / Farmer Jeb (voice) / 导演 Conrad VernonMan on Cell / Woman (voice) / 编剧 
