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Filmography
| 2025 | Animal Farm · as Carl (voice) |
| 2022 | Spoiler Alert · as Michael Ausiello |
| 2020 | Truman & Tennessee: An Intimate Conversation · as Truman Capote (voice) |
| 2020 | The Boys in the Band · as Michael |
| 2020 | Staged · as Jim |
| 2020 | Hollywood (2020) · as Henry Wilson |
| 2019 | Extremely Wicked, Shockingly Evil and Vile · as Florida Prosecutor Larry Simpson |
| 2018 | The 2000s · as Actor, The Big Bang TheoryEn Plex |
| 2018 | A Kid Like Jake · as Greg Wheeler |
| 2017 | Pete the Cat · as Stan (voice) |
| 2017 | Michael Jackson's Halloween · as Hay Man (voice) |
| 2017 | Young Sheldon · as Sheldon Cooper (voice) |
| 2017 | First in Human: The Trials of Building 10 · as Narrator |
| 2016 | Hidden Figures · as Paul Stafford |
| 2015 | SuperMansion · as Mr. Skibumpers |
| 2015 | Visions · as Dr. Mathison |
| 2015 | Larry Kramer in Love and Anger · as Tommy Boatwright |
| 2015 | Home · as Oh (voice) |
| 2014 | Elf: Buddy's Musical Christmas · as Buddy (voice) |
| 2014 | Wish I Was Here · as Paul |
| 2014 | The Normal Heart · as Tommy Boatwright |
| 2012 | Family Guy: 200 Episodes Later · as Gayjacker |
| 2012 | The High Fructose Adventures of Annoying Orange · as Henry Applesauce |
| 2012 | Sunset Stories · as Prince |
| 2011 | The Muppets · as Human Walter |
| 2011 | The Big Year · as Crane |
| 2010 | Pound Puppies (2010) · as Milton Feltwaddle (voice) |
| 2010 | Kick Buttowski: Suburban Daredevil · as Larry Wilder |
| 2009 | The Super Hero Squad Show · as Nightmare |
| 2009 | Glenn Martin DDS · as Draven (voice) |
| 2007 | The Big Bang Theory · as Sheldon Cooper |
| 2007 | iCarly · as Caleb |
| 2007 | Gardener of Eden · as Spim |
| 2007 | On the Road with Judas · as Jimmy Pea |
| 2006 | School for Scoundrels · as ClassmateEn Plex |
| 2006 | 10 Items or Less · as ReceptionistEn Plex |
| 2006 | Eureka · as Carl The Jeep |
| 2006 | Unaired Pilot · as Sheldon Cooper |
| 2005 | Heights · as Oliver |
| 2005 | The Great New Wonderful · as Justin |
| 2004 | Garden State · as Tim |
| 2003 | Blitt Happens · as Mike |
| 2003 | Happy End · as Casting Assistant |
| 2000 | Ed · as Chet |
| 1999 | Judging Amy · as Rob Holbrook |
| 1999 | Family Guy · as Sheldon Cooper (voice) |
| 1989 | The Simpsons · as Jim Parsons (voice) |
| 2022 | |
| 2021 | Call Me Kat · as Executive Producer |
| 2020 | Equal · as Executive Producer |
| 2020 | Hollywood (2020) · as Executive Producer |
| 2019 | Special · as Executive Producer |
| 2018 | |
| 2017 | Young Sheldon · as Executive Producer |
| 2017 | First in Human: The Trials of Building 10 · as Executive Producer |
| 2014 |
| 2005 |