MS
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Melissa De Sousa Filmography
| 2025 | Operation: Aunties · as Carol |
| 2022 | The Best Man: The Final Chapters (TV Series) · as Shelby |
| 2022 | Amores que Engañan (TV Series) · as Mariana |
| 2022 | Bel-Air (TV Series) · as Steph |
| 2021 | Our Kind of People (TV Series) · as Alex Rivera |
| 2019 | On Becoming a God in Central Florida (TV Series) · as Mirta Herrera |
| 2018 | Ladies of the Law (2018) (TV Series) · as Tina |
| 2018 | Black Lightning (TV Series) · as Chief Ana Lopez |
| 2015 | Supermodel · as Det. Lacey |
| 2014 | Cru · as Michelle Hughes |
| 2013 | The Best Man Holiday · as Shelby |
| 2013 | Noches con Platanito (TV Series) · as Guest |
| 2012 | Elementary (TV Series) · as Luz Horowitz |
| 2012 | Family Time (TV Series) · as Shauna |
| 2011 | 2011 Soul Train Awards · as Heself |
| 2011 | Reed Between the Lines (TV Series) · as Gabriella Jimenez |
| 2011 | Single Ladies (TV Series) · as Austin Aguilera |
| 2011 | Shameless (US) (TV Series) · as Tina |
| 2010 | |
| 2010 | The Bannen Way · as Catalina |
| 2009 | Divas · as Angie |
| 2009 | Castle (2009) (TV Series) · as Liz Penn |
| 2008 | A Good Man Is Hard to Find · as Monica |
| 2007 | Bats: Human Harvest · as O'neal |
| 2006 | The Ron Clark Story · as Marissa Vega |
| 2005 | Constellation · as Lucy Boxer |
| 2005 | Ghost Whisperer (TV Series) · as Christine Nelson |
| 2005 | Criminal Minds (TV Series) · as Adele Mccord |
| 2004 | Second Time Around (2004) (TV Series) · as Coco Herrera |
| 2003 | Biker Boyz · as Sheila |
| 2002 | Laurel Canyon · as Claudia |
| 2001 | |
| 2001 | One On One (TV Series) · as Natalie |
| 2000 | Miss Congeniality · as Karen Krantz |
| 2000 | The $treet (TV Series) · as Donna Pasqua |
| 2000 | Lockdown · as Krista |
| 1999 | The Best Man · as Shelby |
| 1999 | |
| 1998 | Ride · as Leta |
| 1998 | Damon (TV Series) · as Stacy Phillips |
| 1996 | Moesha (TV Series) · as Jennifer |
| 1995 | Simon (TV Series) · as Brenda |
| 1995 | The Wayans Bros. (TV Series) · as Charmaine |
| 1994 | ER (TV Series) · as Estella |
| 1994 | Valley of the Dolls (TV Series) · as Neely O'hara |
| 1993 | The Sinbad Show (TV Series) · as Cast |
| 1993 | Living Single (TV Series) · as Lisa |
| 1993 | Getting By (TV Series) · as Randee |
| 1991 | Silk Stalkings (TV Series) · as Ellie Rose |
| 1990 | The Trials of Rosie O'Neill (TV Series) · as Cricket |
| 1987 | Married... with Children (TV Series) · as Jaclyn |
| 1984 | CBS Schoolbreak Special (TV Series) · as Melissa Skyler |
| 2019 | The Kelly Clarkson Show (TV Series) · as Self |
| 2014 | 22nd Annual Trumpet Awards · as Self - Host |
| 2014 | Unsung Hollywood (TV Series) · as Self |
| 2013 | The Arsenio Hall Show (2013) (TV Series) · as Self - Guest |
| 2013 | BET Awards 2013 · as Self |
| 2012 | Bethenny (TV Series) · as Self - Guest |
| 2010 | The Talk (TV Series) · as Self - Guest |
| 2008 | The Wendy Williams Show (TV Series) · as Self - Guest |
| 2005 | Made In Hollywood (TV Series) · as Self |
| 2004 | The Insider (TV Series) · as Self |
| 2001 | Good Day Live (TV Series) · as Self |
| 1990 | Christmas In Rockefeller Center (TV Series) · as Self |
| 1981 | Entertainment Tonight (TV Series) · as Self |